Fungal nail infections FAQ

Is this product suitable for use by diabetics?

Excilor® physically impedes the growth of infectious fungi by reducing the pH value of the nail (making it more acidic). This is not a pharmacological effect so there are no contraindications for diabetics. A combination of acidic substances penetrates the nail creating an environment that is hostile to dermatophytes (the fungi responsible for mycosis). The action is localised and targeted. Nonetheless it is recommend that diabetics with foot problems consult their doctor when starting to use Excilor nail fungus treatment (including ULTRA).

My nail has a fungal infection. How long will it take to eliminate the fungus?

As explained on the packaging the product should be applied to the affected nail(s) twice a day until the nail has grown back as a normal healthy nail. By then the patches and/or spots should have disappeared or the nail is no longer thickened or brittle.

A nail only grows about 1.5 mm a month. Excilor® not only makes the white/yellow patches on your nail disappear. More importantly – it gets rid of the actual micro-organisms (the dermatophytes or fungi) which live under your fingernail or toenail. It can take several weeks to make all the micro-organisms disappear. Meanwhile the healthy nail grows back and if you regularly trim the nail using nail clippers the dis-colouration will gradually vanish.

Is this product suitable for children?

No clinical data is available on whether Excilor can be used by children.

Is this product suitable when pregnant?

No clinical data is available on the use of this product during pregnancy.

My child put the Excilor® product in his/her mouth. What should I do?

The product's contents are not toxic but may irritate the mucous lining of the eyes, nose or mouth. The product cannot be opened so children cannot access the contents directly. Because Excilor® has a bitter taste your child is unlikely to swallow or ingest it deliberately. If the product comes into contact with the eyes or inside of the mouth rinse them out using plenty of water.

The instructions advised me to “clean the nail and remove any traces of nail polish” before each application. Can I simply clean the nail with soap and water or should I always use nail polish remover?

You only have to use nail polish remover if the nail is covered with nail polish. If Excilor® is used on nail polish it can partially dissolve the nail polish – this in turn contaminates the product so it no longer works properly. Excilor® is unable to penetrate nail polish as effectively. It is important that nail polish is removed using nail polish remover so Excilor® pcan penetrate the nail and reach the infected area.

Warts FAQ

What is freeze therapy?
Freeze therapy is based on the technique that is used by general practitioners to remove a wart. It freezes the tissue of the wart by applying a very low temperature (-45℃). The body is then able to clear the virus and the wart is removed.
What is gel treatment?
The most commonly used over-the-counter products to remove warts exert their effect based on their acidic nature. TCA-Active™ is a uniquely formulated gel containing a caustic/corrosive agent that causes coagulation of cellular proteins, inducing destruction of keratotic tissue.
How does Freeze Acid 2-Compartment work?
Freeze Acid 2-Compartment is a Self-Care Medical Device for an effective and fast-acting treatment of common warts and foot warts. Freeze Acid 2-Compartment consists of a combination of 2 products. The blue freeze reservoir contains a freezing agent ( Freeze-Active™ ) and the white gel applicator contains a treatment gel (TCA-Active™), combining freeze therapy and gel treatment in one device. Freeze Acid 2-Compartment combines the 2 most common wart treatments for faster results. By rapidly freezing (-45 ℃) the core of the wart and peeling of the infected skin, the thickened skin of the wart and its causative virus are removed and new healthy skin will appear.
What are the active ingredients of Freeze Acid 2-Compartment?
The Active Medical Ingredients in Freeze Acid 2-Compartment are Freeze-Active™ (freezing agent) and TCA-Active™ (based on Trichloroacetic Acid).
How successful is the product when used during 1 treatment cycle (= 5 days)?
It has been shown that after one treatment cycle, Cryo Acid 2-Compartment effectively removes 62.5% of the warts. After three treatment cycles, 87.5% of the warts have been shown to be effectively removed.
What does clinically proven mean?
In addition to an abundance of scientific literature investigating both treatments separately, a recently performed clinical study by Medical Brands has proven that Cryo Acid 2-Compartment effectively removes 87.5% of the warts in a maximum of three treatment cycles when used according to the Instructions for Use.
How is this product different/better than other products on the market?
This product is a combination of the most effective over-the-counter treatments for warts currently available: cryotherapy with Cryo-Active™ and gel treatment with TCA-Active™. Combining both therapies in one treatment cycle shows an improved success rate compared with therapy with either treatment alone.
How long does treatment with Freeze Acid 2-Compartment take?
One treatment cycle with Freeze Acid 2-Compartment takes five days. The treatment cycle may be repeated up to three times, if needed. In between each treatment cycle a resting period of four to seven days is recommended.
What is the treatment cycle?
One treatment cycle with Cryo Acid 2-Compartment takes five days. On the first day of treatment only cryotherapy is applied and on the following four days gel treatment is applied twice daily (once daily for children aged 4-12). If the wart is not fully removed, the treatment cycle may be repeated twice after a resting period of 4-7 days.
How often can I use this treatment?
A maximum of three treatment cycles is recommended. If the treated wart does not disappear after three completed cycles, please contact your general practitioner for medical advice.
Which items are in the box?
  • One device containing 2 products: one cryo reservoir with foam holder plus foam and one
    gel applicator
  • Foam bag containing 5 foams
  • Instructions for Use
How do I prepare for the treatment?
You will need tissues and a timer to perform the treatment. When treating a wart covered by callus, it is advisable to first soak the foot in lukewarm water for 5 minutes and rub the callus carefully with a file prior to the treatment.
How do I open Freeze Acid 2-Compartment ?

Freeze Acid 2-Compartment consists of two products, for each phase of the treatment cycle. For cryotherapy on day 1, to open product 1, twist the black foam holder from the closed lock symbol towards the open lock symbol as shown in the Instructions for Use.


For the gel treatment on Days 2,3,4,5, to open product 2, twist the white gel applicator to align the drop symbol with the open lock symbol. Once separated, you turn the dial of the gel applicator clockwise as indicated in the Instructions for Use.

How do I avoid exposure of healthy skin to Freeze Acid 2-Compartment?
The foam provided allows precise application to the wart only. Before applying the gel treatment, an ointment such as vaseline can be used to protect the surrounding skin.
What do I do when I accidentally exposed healthy skin to Freeze Acid 2-Compartment?

When healthy skin is exposed to freeze therapy, a frostbite may develop. This can be mildly painful but typically heals without medical intervention.


When healthy skin is exposed to the gel treatment, rinse the complete area with excessive water and soap and re-apply the gel to the wart only.

Can I let the treated area get wet?
Wait for 10-15 minutes before exposing the treated area to water or otherwise.
Can I expose the treated skin to sunlight?
To avoid skin hyper- or hypo-pigmentation which may occur because of sunlight exposure, do not expose the skin to sunlight for 4 to 6 weeks.
What is the best way to take care of the treated area?
It is important to keep the treated area clean and do not touch or pick the treated skin, because a wart is contagious. Do not peel off the scab as it needs to fall off by itself. If a blister forms, do not puncture it.
How can I determine if the wart has been fully removed?

To verify whether the wart has been removed, you could soak the treated area in lukewarm water for 5 minutes and rub the calls carefully with a file. If the skin does not show little black dots (little blood vessels, typical for a wart), the wart has been removed.


During the treatment, a layer of callus (hardened skin layer) will form. The callus is not a wart. The callus might need a couple of weeks to wear before the optimal result is seen. Renewed skin will appear smoother, slightly pink and regain its natural colour within subsequent weeks.

Can a successfully treated wart re-appear?
Treatment with Cryo Acid 2-Compartment removes the tissue that is affected by the underlying virus infection that causes warts to occur. The body is then better capable of eliminating the virus.
How many warts can I treat at once?
When used for the first time, treat only one wart before treating multiple warts, to experience the effect on your skin . Start treating another wart only if you did not experience any side effects (normally within 5 days). If there are multiple warts close to one another (within 1 cm) , wait until the skin has returned to normal before treating another wart (this can take up to 6 weeks).
Are there any side effects to expect?
  • Complications are infrequent. It is extremely rare that a permanent mark or scar will occur. This could mostly be related to an abnormality such as healing disorders or infection. If so, please consult your general practitioner.
  • As with all freezing methods, the skin may turn white temporarily.
  • Application of the freezing agent may cause a stinging, itching, aching feeling during and after freezing that quickly decreases after the area thaws.
  • Overexposure to the freezing product could cause damage to the top layers of the skin, resulting in scars and/or may lead to nerve damage.
Can Freeze Acid 2-Compartment be used by diabetics?
Please consult your treating physician before starting treatment with Freeze Acid 2-Compartment if you are diabetic.
Can I use Freeze Acid 2-Compartment when pregnant?
Please consult your general practitioner before starting treatment with Freeze Acid 2-Compartment if you are pregnant.
Can Freeze Acid 2-Compartment be used on children?
Freeze Acid 2-Compartment can be used by adults and children from 4 years old. Adults should apply the treatment to children.
If one of the ingredients is accidentally swallowed or inhaled, what should I do?

Avoid inhaling of the freezing agent by only performing the treatment in a well ventilated area. If you accidentally inhale the freezing agent and you are experiencing complaints, please consult the emergency department of the hospital.


If you accidentally ingest the gel, please consult the emergency department of the hospital.

If one of the ingredients accidentally comes in contact with the eye or mucosal tissue, what should I do?
In case the gel accidentally comes in contact with eyes or mucosal membranes, rinse with plenty of water and seek medical assistance.
When should Freeze Acid 2-Compartment not be used?
  • If the wart is located on an area other than the hand or foot
  • On a bleeding, irritated, inflamed skin or skin showing any sign of inflammation such as itch or swelling
  • On skin tags, moles, dark patches of skin, freckles, water warts (mollusca contagiosa), seborrhoeic keratosis (verruca seborrhoica), or exfoliated skin
  • If you have any doubt if the condition is a wart
  • If you are hypersensitive to one of the ingredients.
Is treatment with Freeze Acid 2-Compartment painful?
In general, freeze therapy (on Day 1 of the treatment cycle only) is not considered painful when applied to affected skin, but may cause some transient unpleasantness or stinging sensation. During the clinical study performed by Medical Brands, the participants indicated on average to experience very mild pain during and after treatment. Application of gel treatment (Day 2-5) may cause minor short-lasting skin irritation. This should be resolved before the next gel application.
Can Freeze Acid 2-Compartment be used by different users?
To maintain personal hygiene the treatment should only be used by a single user.
What is the shelf-life of Freeze Acid 2-Compartment after opening?
After opening Freeze Acid 2-Compartment should be discarded after 6 months. Do not use after the expiry date as printed on the package.
Is Freeze Acid 2-Compartment difficult to use?
No. The instructions need to be followed carefully and accurately, but it is not difficult to perform the treatment.
Is Freeze Acid 2-Compartment safe to use?
Yes. The Instructions for Use need to be followed carefully and accurately, and then Freeze Acid 2-Compartment is safe to use.
Can I re-use the foam?
The foam is for single use only.
How many treatment cycles can be performed with one device?
One packaging contains enough to perform 5 treatment cycles.
How do I store Freeze Acid 2-Compartment?
Please store at room temperature (15-25°C) and avoid exposure to direct sunlight.
Where can I buy Freeze Acid 2-Compartment?
You can buy Freeze Acid 2-Compartment at the pharmacy and/or drugstore.